Cobalt’s instruments for pharmaceutical analysis dramatically reduce costs in Quality Control
Raw Materials Identification Without Opening the Container
RapIDTM uses Cobalt's unique Spatially Offset Raman Spectroscopy (SORSTM) technology to identify raw materials through unopened containers, including multi-layered paper and plastic sacks, thick amber glass, plastic tubs and super-sacks/FIBCs. Measurements take seconds and, by avoiding sampling steps, more containers can be tested per hour with less resource.
- Up to 10x increase in testing throughput
- Makes 100% raw materials ID cost-effective
- No sampling booths
- No contamination of sterile materials
- Works with a wide variety of containers and materials
Other Raman technologies require most containers to be opened before measurements can be taken. Opening containers needs a sampling booth and protective clothing – for sacks, the time taken can be 10x longer per sack than when using RapID.
Content Uniformity, Polymorph and Blend Analysis
Transmission Raman is sensitive and fast – a full tray of 100-200 tablets or capsules typically takes minutes to analyse for API, excipient and polymorph content.
TRS is a viable alternative to HPLC for content uniformity (CU) analysis. Methods for CU testing have been approved by regulators. The TRS100 is a fully-automated tablet testing instrument designed for routine high-throughput CU testing.
- Full CU batch test in <5 minutes
- No sample preparation
- No consumables/solvents
- API levels as low as 0.1-1%
- Save $500 or more per CU batch test
TRS analysis is an ideal alternative to NIR spectroscopy as it is much less affected by particle size, tablet compaction and moisture content, making robust methods easier and quicker to create.
The TRS100 is also employed in routine analysis in pharma R&D labs, with applications including polymorph and blend analysis.