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Selected Peer-Reviewed Publications on SORS/TRS Concepts


2017

Calibration Transfer of a Quantitative Transmission Raman PLS Model: Direct Transfer vs. Global Modeling, Douglas Steinbach, Carl A. Anderson, Gary McGeorge, Benoit Igne, Robert W. Bondi, James K. Drennen III, J. Pharm. Innovation, 4 (2017), 347-356.

Through-container, extremely low concentration detection of multiple chemical markers of counterfeit alcohol using a handheld SORS device, David I. Ellis, Rebecca Eccles, Yun Xu, Julia Griffen, Howbeer Muhamadali, Pavel Matousek, Ian Goodall & Royston Goodacre, Scientific Reports, 7, 12082 (2017).

Discovering Hidden Painted Images: Subsurface Imaging Using Microscale Spatially Offset Raman Spectroscopy, A. Botteon, C. Conti, M. Realini, C. Colombo, P. Matousek, Analytical Chemistry, 89 (2017), 792-798.

Recent Advances in Pharmaceutical Analysis Using Transmission Raman Spectroscopy, J. Griffen, A. Owen, D. Andrews, P. Matousek, Spectroscopy, 32 (4) (2017), 37-43.

Investigation of the Sensitivity of Transmission Raman Spectroscopy for Polymorph Detection in Pharmaceutical Tablets, H. Feng, R. W. Bondi Jr, C. A. Anderson, J. K. Drennen III, B. Igne, Applied Spectroscopy, Published online March 30th 2017.

Frozen in Time: Kinetically Stabilized Amorphous Solid Dispersions of Nifedipine Stable after a Quarter Century of Storage, F. Theil, S. Anantharaman, S. O. Kyeremateng, H. van Lishaut, S. H. Dreis-Kühne, J. Rosenberg, M. Mägerlein, G. H. Woehrle - AbbVie Deutschland GmbH - Molecular Pharmaceutics, 14 (2017), 183−192.


2016

How far can we go with the analysis of capsule-based dry powder inhalers?, M. Bautista, F. Tosini, M. Schneider, S. Steigmiller - Novartis Pharma AG - European Pharmaceutical Review, 6 (2016), 24-28.

Non-invasive Chemically Specific Measurement of Subsurface Temperature in Biological Tissues using Surface Enhanced Spatially Offset Raman Spectroscopy, B. Gardner, N. Stone, P. Matousek, Faraday Discussions, 187 (2016), 329-339.

The performance of Spatially Offset Raman Spectroscopy for liquid explosive detection, P. Loeffen, G. Maskall, S. Bonthron, M. Bloomfield, C. Tombling, P. Matousek, Proc. SPIE 9995, Optics and Photonics for Counterterrorism, Crime Fighting, and Defence XII, 99950D.

Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring, P. Matousek, N. Stone, Chemical Society Reviews, 45 (2016), 1794-1802.

Micro-scale spatially offset Raman spectroscopy for non-invasive subsurface analysis of turbid materials, P. Matousek, C. Conti, M. Realini, C. Colombo, Analyst, 141 (2016), 731-739.

Photon migration of Raman signal in bone as measured with spatially offset Raman spectroscopy, K. Sowoidnich, J. Churchwell, K. Buckley, A.E. Goodship, A.W. Parker, P. Matousek, Journal of Raman Spectroscopy, 47 (2016), 240-247.

New capability for hazardous materials ID within sealed containers using a portable spatially offset Raman spectroscopy (SORS) device, R. J. Stokes, M. Bailey, S. Bonthron, T. Stone, G. Maskell, O. Presly, E. Roy, C. Tombling, P. W. Loeffen, Proc. SPIE 9995, Optics and Photonics for Counterterrorism, Crime Fighting, and Defence XII, 999505.

Temperature Spatially Offset Raman Spectroscopy (T-SORS): Subsurface Chemically Specific Measurement of Temperature in Turbid Media Using Anti-Stokes Spatially Offset Raman Spectroscopy, B. Gardner, P. Matousek, N. Stone, Analytical Chemistry, 88 (2016), 832-837.

Method Development and Validation for Pharmaceutical Tablets Analysis using Transmission Raman Spectroscopy, Y. Li, B. Igne, J. K. Drennen III, C. A. Anderson, International Journal of Pharmaceutics, 498 Issues 1-2 (2016), 318-325.

Rapid Quantification of Low Level Polymorph Content in a Solid Dose Form using Transmission Raman Spectroscopy, J. Griffen, A. Owen, J. Burley, V. Baresco, P. Matousek, Journal of Pharmaceutical and Biomedical Analysis, 128 (2016), 35-45.

Fast Non-Destructive Detection of Low Level Crystalline Forms in Amorphous Spray Dried Dispersion Using Transmission Raman Spectroscopy and Comparison to Solid-State NMR Spectroscopy
A. Kumar, J. Lubach, J. Griffen, J. Wang, C. Y. Tsang, J. Hau, M. Bloomfield, P. Matousek, L. Wigman, American Pharmaceutical Review, Published online January 31st 2016.


2015

Comprehensive Quantification of Tablets with Multiple Active Pharmaceutical Ingredients using Transmission Raman Spectroscopy - A Proof of Concept Study, J. Griffen, A. Owen, P. Matousek, Journal of Pharmaceutical and Biomedical Analysis, Published online July 26th 2015.

Noninvasive Analysis of Thin Turbid Layers Using Microscale Spatially Offset Raman Spectroscopy, C. Conti, M. Realini, C. Colombo, K. Sowoidnich, N. K. Afseth, M. Bertasa, A. Botteon, P. Matousek, Analytical Chemistry, 87 (2015), 5810-5815.

Quantitative Analysis of Pharmaceutical Bilayer Tablets Using Transmission Raman Spectroscopy, Y. Zhang, G. McGeorge, Journal of Pharmaceutical Innovation, Published online June 16th 2015.

The use of laser spectroscopy to investigate bone disease in King Henry VIII's sailors, J. Kerns, K. Buckley, A. Parker, H. Birch, P. Matousek, A. Hildred, A. Goodship, Journal of Archaeological Science 53 (2015), 516-520.

Towards the in vivo prediction of fragility fractures with Raman spectroscopy: Prediction of fragility fractures with Raman spectroscopy, K. Buckley, J.G. Kerns, J. Vinton, P.D. Gikas, C. Smith, A.W. Parker, P. Matousek, A.E. Goodship, Journal of Raman Spectroscopy, 46 (2015), 610-618.

Subsurface analysis of painted sculptures and plasters using micrometre-scale spatially offset Raman spectroscopy (micro-SORS), C. Conti, C. Colombo, M. Realini, P. Matousek, Journal of Raman Spectroscopy, 46 (2015), 476-482.


2014

Development of Transmission Raman Spectroscopy towards the in line, high throughput and non-destructive quantitative analysis of pharmaceutical solid oral dose, J. A. Griffen, A. W. Owen, P. Matousek, Analyst 140 (2015), 107-112 - published as HOT article November 2014.

Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy, K. Buckley, J Kerns, P Gikas, H. Birch, J. Vinton, R. Keen, A. Parker, P. Matousek, A. Goodship, IBMS BoneKEy, 11 (2014), 602.

Subsurface Raman Analysis of Thin Painted Layers, C. Conti, C, Colombo, M. Realini, G. Zerbi, P. Matousek, Applied Spectroscopy, 68 (2014), 686-691.

A Novel Approach for Subsurface Through-Skin Analysis of Salmon Using Spatially Offset Raman Spectroscopy (SORS), N.K. Afseth, M. Bloomfield, J.P. Wold, P. Matousek, Applied Spectroscopy, 68 (2014), 255-262.

Quantification of pharmaceuticals via transmission Raman spectroscopy: data sub-selection, J.C. Burley, A. Aina, P. Matousek, C. Brignell, Analyst, 139 (2014), 74-78.


2013

Non-invasive identification of incoming raw pharmaceutical materials using Spatially Offset Raman Spectroscopy, M. Bloomfield, D. Andrews, P. Loeffen, C. Tombling, T. York, P. Matousek, Journal of Pharmaceutical and Biomedical Analysis 76 (2013) 65-59.

Recent advances in the development of Raman spectroscopy for deep non-invasive medical diagnosis, P. Matousek, N. Stone, Journal of Biophotonics, 6 (2013), 7-19.


2012

Transmission Raman spectroscopy for quality control in model cocrystal tablets, J.C. Burley, A. Alkhalil, M. Bloomfield, P. Matousek, Analyst, 137 (2012), 3052-3057.

Pharmaceutical polymorphs quantified with transmission Raman spectroscopy, C.M. McGoverin, M.D. Hargreaves, P. Matousek, K.C. Gordon, Journal of Raman Spectroscopy, 43 (2012), 280-285.


2011

Spatially Offset Raman Spectroscopy (SORS) for Liquid Screening, P. Loeffen, G. Maskall, S. Bonthron, M. Bloomfield, C. Tombling, P. Matousek, “Optics and Photonics for Counterterrorism and Crime Fighting VII; Optical Materials in Defence Systems Technology VIII; and Quantum-Physics-based Information Security”, Proc. of SPIE Vol. 8189 (2011) 81890C-1 - 81890C-10, Editors: Lewis, Burgess, Zamboni, Kajzar, Szep, Gruneisen, Dusek, Rarity.

Dependence of Signal on Depth in Transmission Raman Spectroscopy, P. Matousek, N. Everall, D. Littlejohn, A. Nordon, M. Bloomfield, Applied Spectroscopy 65 (2011) 724-733.

Chemical and explosives point detection through opaque containers using spatially offset Raman spectroscopy (SORS), Paul W. Loeffen, Guy Maskall, Stuart Bonthron, Matthew Bloomfield, and Craig Tombling. Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII. Proc. SPIE 8018, 80181E (2011)

Spatially Offset Raman Spectroscopy (SORS) for Liquid Screening. SPIE Security & Defence Europe, Prague, 2011. Paul W. Loeffen, Guy Maskall, Stuart Bonthron, Matthew Bloomfield, Craig Tombling, Pavel Matousek.

P. Matousek, F. Thorley, P. Chen, M. Hargreaves, C. Tombling, P. Loeffen, M. Bloomfield, D. Andrews, Emerging Raman Techniques for Rapid Noninvasive Characterization of Pharmaceutical Samples and Containers, Spectroscopy 26 (2011) 44-51.

Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging – the next dimension, N. Stone, M. Kerssens, G.R. Lloyd, K. Faulds, D. Graham, P. Matousek, Chemical Science, 2 (2011), 776-780.

Non-invasive analysis of turbid samples using deep Raman spectroscopy, K. Buckley, P. Matousek, Analyst, 136 (2011), 3039-3050.

Recent advances in the application of transmission Raman spectroscopy to pharmaceutical analysis, K. Buckley, P. Matousek, J. Pharm. Biomed. Anal., 55 (2011), 645-652.

M.D. Hargreaves, N.A. Macleod, M.R. Smith, D. Andrews, S.V. Hammond, P. Matousek, Characterisation of Transmission Raman Spectroscopy for Rapid Quantitative Analysis of Intact Multi-component Pharmaceutical Capsules, Journal of Pharmaceutical and Biomedical Analysis, 54 (2011), 463-468.


2010

Towards a safe non-invasive method for evaluating the carbonate substitution levels of hydroxyapatite (HAP) in micro-calcifications found in breast tissue, M.M. Kerssens, P. Matousek, K. Rogers, N. Stone, Analyst, 135 (2010), 3156-3161.

Transmission Raman Spectroscopy as a tool for quantifying polymorphic content of pharmaceutical formulations, A. Aina, M.D. Hargreaves, P. Matousek, J.C. Burley, Analyst, 135 (2010), 2328.

M.A. Elbagerma, H.G.M. Edwards, T.Munshi, M.D. Hargreaves, P. Matousek, I.J. Scowen, Characterization of New Cocrystals by Raman Spectroscopy, Powder X-ray Diffraction, Differential Scanning Calorimetry, and Transmission Raman Spectroscopy, Crystal Growth & Design, 10 (2010), 2360.

N. Stone, K. Faulds, D. Graham, P. Matousek, Prospects of Deep Raman Spectroscopy for Noninvasive Detection of Conjugated Surface Enhanced Resonance Raman Scattering Nanoparticles Buried within 25 mm of Mammalian Tissue, Anal. Chem., 82 (2010), 3969.

M. Bloomfield, P.W. Loeffen, P. Matousek, Detection of concealed substances in sealed opaque plastic and coloured glass containers using SORS, “Optics and Photonics for Counterterrorism and Crime Fighting VI and Optical Materials in Defence Systems Technology VII”, Proceedings of SPIE 7838: 783808-1 (2010) Editors: C. Lewis, D. Burgess, R. Zamboni, F. Kajzar, E.M. Heckman.

P. Matousek, Spatially Offset Raman Spectroscopy - Emerging Concepts and Applications, Editors: P.M. Champion, L.D. Ziegler, XXII International Conference on Raman Spectrscopy, AIP Conference Proceedings, Volume: 1267, Pages: 16-17, 2010.

N. Everall, P. Matousek, N. Macleod, K.L. Ronayne, I.P. Clark, Temporal and Spatial Resolution in Transmission Raman Spectroscopy, Applied Spectroscopy, 64 (2010), 52.


2009

M.D. Hargreaves, P. Matousek, Threat detection of liquid explosive precursor mixtures by Spatially Offset Raman Spectroscopy (SORS), “Optics and Photonics for Counterterrorism and Crime Fighting V”, Proceedings of SPIE 7486(1): 74860B - 74860B-7 (2009) Editor: Colin Lewis.

M.D. Hargreaves, N.A. Macleod, V.L. Brewster, T. Munshi, H.G.M. Edwards, P. Matousek ‘Application of Portable Raman Spectroscopy & Spatially Offset Raman Spectroscopy (SORS) to Interrogate Concealed Biomaterials’, Journal of Raman Spectroscopy, 40 (2009), 1875.

P. Matousek, N. Stone, ‘Emerging Concepts in Deep Raman Spectroscopy of Biological Tissue’, Analyst, 134 (2009), 1058.


2008

N.A. Macleod, P. Matousek, ‘Deep Noninvasive Raman Spectroscopy of Turbid Media’, Applied Spectroscopy 62 (2008) 276A.

N.A. Macleod, A. Goodship, A.W. Parker, P. Matousek, ‘Prediction of Sublayer Depth in Turbid Media Using Spatially Offset Raman Spectroscopy’, Analytical Chemistry, 80 (2008), 8146.

N.A. Macleod, P. Matousek, ‘Emerging Non-invasive Raman Methods in Process Control and Forensic Applications’, Pharmaceutical Research, 25 (2008), 2205.

C. Eliasson, N.A. Macleod, P. Matousek, ‘Non-invasive Detection of Powders Concealed within Diffusely Scattering Plastic Containers’, Vibrational Spectroscopy, 48 (2008), 8.

K. Buckley, A. Goodship, N.A. Macleod, A.W. Parker, P. Matousek, ‘Technique for Enhancing Signal in Conventional Backscattering Fluorescence and Raman Spectroscopy of Turbid Media’, Anal. Chem., 80 (2008), 6006.

C. Eliasson, P. Matousek, ‘Passive Signal Enhancement in Spatially Offset Raman Spectroscopy’,Journal of Raman Spectroscopy, 39 (2008), 633.

C. Eliasson, N.A. Macleod, P. Matousek, ‘Non-invasive Detection of Cocaine Dissolved in Beverages using Displaced Raman Spectroscopy’, Analytica Chimica Acta, 607 (2008), 50.

N. Stone, P. Matousek, Advanced Transmission Raman Spectroscopy: A Promising Tool for Breast Disease Diagnosis, Cancer Research, 68 (2008), 4424.

C. Eliasson, N.A. Macleod, L.C. Jayes, F.C. Clarke, S.V. Hammond, M.R. Smith, P. Matousek, Non-Invasive Quantitative Assessment of the Content of Pharmaceutical Capsules using Transmission Raman Spectroscopy, Journal of Pharmaceutical and Biomedical Analysis, 47 (2008), 221.


2007

P. Matousek, 'Review of Deep Non-invasive Raman Spectroscopy of Living Tissue and Powders',Chemical Society Reviews, 36 (2007), 1292.

N. Stone, R. Baker, K. Rogers, A.W. Parker, P. Matousek, ‘Subsurface probing of calcifications with spatially offset Raman spectroscopy (SORS): future possibilities for the diagnosis of breast cancer’, Analyst, 132 (2007), 899.

C. Eliasson, M. Claybourn, P. Matousek, 'Deep Subsurface Raman Spectroscopy of Turbid Media by Defocused Collection System', Applied Spectroscopy, 61 (2007), 1123.

P. Matousek, 'Raman Signal Enhancement in Deep Spectroscopy of Turbid Media', Applied Spectroscopy, 61 (2007) 845.

C. Eliasson, N.A. Macleod, P. Matousek, 'Non-invasive Detection of Concealed Liquid Explosives using Raman Spectroscopy', Analytical Chemistry, 79 (2007), 8185.

C. Eliasson, P. Matousek, ‘Non-Invasive Authentication of Pharmaceutical Products through Packaging using Spatially Offset Raman Spectroscopy’, Analytical Chemistry, 79 (2007), 1696.

P. Matousek, N. Stone, ‘Prospects for the Diagnosis of Breast Cancer by Non-Invasive Probing of Calcifications using Transmission Raman Spectroscopy’, Journal of Biomedical Optics, 12 (2007), 024008.

P. Matousek, A.W. Parker, ‘Non-Invasive Probing of Pharmaceutical Capsules using Transmission Raman Spectroscopy’, Journal of Raman Spectroscopy, 38 (2007), 563.

R. Baker, P. Matousek, K.L. Ronayne, A.W. Parker, K. Rogers, N. Stone, 'Depth profiling of calcifications in breast tissue using picosecond Kerr gated Raman spectroscopy', The Analyst, 132 (2007), 48.


2006

P. Matousek, A.W. Parker, ‘Bulk Raman Analysis of Turbid Media’, Applied Spectroscopy, 60 (2006), 1353.

P. Matousek, Inverse Spatially Offset Raman Spectroscopy for Deep Noninvasive Probing of Turbid Media’, Applied Spectroscopy, 60 (2006), 1341.

P. Matousek, E.R.C. Draper, A.E. Goodship, I.P. Clark, K.L. Ronayne, A.W. Parker, ‘Noninvasive Raman Spectroscopy of Human Tissue In Vivo’, Applied Spectroscopy, 60 (2006), 758.


2005

P. Matousek, M.D. Morris, N. Everall, I.P. Clark, M. Towrie, E. Draper, A. Goodship, A. W. Parker, ‘Numerical Simulations of Subsurface Probing in Diffusely Scattering Media using Spatially Offset Raman Spectroscopy’, Applied Spectroscopy, 59 (2005), 1485.

P. Matousek, I.P. Clark, E.R.C. Draper, M.D. Morris, A.E. Goodship, N. Everall, M. Towrie, W.F. Finney, A.W. Parker, ‘Subsurface Probing in Diffusely Scattering Media using Spatially Offset Raman Spectroscopy’, Applied Spectroscopy, 59 (2005), 393.

E.R.C. Draper, M.D. Morris, N.P. Camacho, P. Matousek, M. Towrie, A.W. Parker, A.E. Goodship, ‘Novel Assessment of Bone using Time-Resolved Transcutaneous Raman Spectroscopy’, Journal of Bone and Mineral Research, 20 (2005), 1968.

P. Matousek, N. Everall, M. Towrie and A. W. Parker, ‘Depth Profiling in Diffusely Scattering Media using Raman Spectroscopy and Picosecond Kerr Gating’, Applied Spectroscopy, 59 (2005), 200.


Books

P. Matousek and M.D. Morris, Eds., Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields, Springer, Heidelberg, 2010.


Book Chapters

2012

Non-invasive Detection of Concealed Liquid and Powder Explosives using Spatially Offset Raman Spectroscopy, K. Buckley, P. Matousek, in Infrared and Raman Spectroscopy in Forensic Science, H.G.M. Edwards, M.D. Hargreaves, J.M. Chalmers, Eds., (Wiley, Chichester, 2012), Chap. 5.4, pp. 289-294.

Non-invasive Detection of Illicit Drugs using Spatially Offset Raman Spectroscopy, K. Buckley, P. Matousek, in Infrared and Raman Spectroscopy in Forensic Science, H.G.M. Edwards, M.D. Hargreaves, J.M. Chalmers, Eds., (Wiley, Chichester, 2012), Chap. 6.2, pp. 351-356.

2010

N.A. Macleod, M.D. Morris, P. Matousek, Deep, Noninvasive Raman Spectroscopy of Diffusely Scattering Media, in Raman Applications and Techniques in Biomedical and Pharmaceutical Fields, P. Matousek and M.D. Morris, Eds. (Springer, Heidelberg, 2010), Chap. 3.

2009

P. Matousek, Deep, Noninvasive Raman Spectroscopy of Diffusely Scattering Media, in Infrared and Raman Spectroscopic Imaging, R. Salzer and H.W. Siesler, Eds. (Wiley-VCH, Weinheim, 2009), Chap. 12, p. 405.

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