Paper published in the Royal Society of Chemistry’s Analyst journal, entitled “Development of Transmission Raman Spectroscopy towards the in line, high throughput and non-destructive quantitative analysis of pharmaceutical solid oral dose”, has been selected as a 'Hot Article' and is open access.
Cobalt’s latest peer-reviewed publication describes use of the TRS100 Transmission Raman system for rapid, quantitative analysis of both Active Pharmaceutical Ingredient (API) and excipient content of pharmaceutical tablets and capsules. The paper describes use of an enhancing element “photon diode” for faster operation, enabling potential deployment in high throughput QC applications in batch or continuous manufacturing processes. The experiments were performed on a complex mixture of 5 components (3 APIs and 2 excipients), with acquisition times as short as 0.01 seconds.
Use of Transmission Raman Spectroscopy is non-destructive and requires neither sample preparation nor skilled operation. This is in contrast to High-Performance Liquid Chromatography (HPLC) – the industry standard technique for content uniformity analysis – where consumable costs are high and frequent, and where results can be affected by operator bias.