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Agilent, formerly Cobalt Light Systems, develops instruments for pharmaceutical analysis that dramatically reduce costs in Quality Control

Raw Materials Identification Without Opening the Container

RapID™ uses Cobalt's unique Spatially Offset Raman Spectroscopy (SORS™) technology to identify raw materials through unopened containers, including multi-layered paper and plastic sacks, thick amber glass, plastic tubs and super-sacks/FIBCs. Measurements take seconds and, by avoiding opening the containers, more can be tested per hour with increased safety and less resource.

  • Up to 10x increase in testing throughput
  • Makes 100% raw materials ID cost-effective
  • No sampling booths
  • No contamination of sterile materials
  • Safe handling of dangerous APIs
  • Works with a wide variety of containers and materials

Other Raman instruments require most containers to be opened to make a measurement; opening containers needs a sampling booth and protective clothing. For conventional Raman ID of paper sacks, the total time taken can be 10x greater than when using RapID.

A revolutionary tool for verifying pharmaceutical materials through unopened sacks, bottles, coloured glass and plastic containers

A revolutionary tool for verifying pharmaceutical materials through unopened sacks, bottles, coloured glass and plastic containers

Content Uniformity, Polymorph and Blend Analysis

The TRS100™ uses Transmission Raman Spectroscopy (TRS™) technology for fast quantitative analysis of intact samples including capsules, tablets, powders, gels and solutions/suspensions.

Transmission Raman is sensitive and fast – a tray of 200 tablets or capsules typically takes minutes to analyse for content uniformity (CU), assay and ID. Excipient content can be determined in the same measurement with no extra time. Other routine applications in pharma R&D labs include polymorph and blend analysis, residual crystallinity and stability testing.

Low-Resource Alternative to HPLC

TRS can be a compelling alternative to resource-intensive methods for CU, assay and ID that are often done by HPLC. TRS100 is a fully-automated tablet testing instrument designed for routine high-throughput CU testing. Regulatory approvals have been granted for CU, assay and ID methods.

  • Full CU batch test in <5 minutes, incl. setup time
  • No sample preparation
  • No consumables/solvents
  • Analyse API levels as low as 0.1-1%